HELAINE LAB

Publications

Publications

Impact of bacterial persisters on their host.
Moldoveanu AL, Rycroft JA, Helaine S.
Curr Opin Microbiol. 2021 Feb;59:65-71. doi:10.1016/j.mib.2020.07.006. Epub 2020 Aug 28.

Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection.
Pham THM, Brewer SM, Thurston T, Massis LM, Honeycutt J, Lugo K, Jacobson AR, Vilches-Moure JG, Hamblin M, Helaine S, Monack DM.
Cell Host Microbe. 2020 Jan 8;27(1):54-67.e5. doi: 10.1016/j.chom.2019.11.011. Epub 2019 Dec 26

Salmonella Effector SteE Converts the Mammalian Serine/Tthreonine Kinase GSK3 into a Tyrosine Kinase to direct Macrophage Polarization.
Panagi I, Jennings E, Zeng J, Günster RA, Stones CD, Mak H, Jin E, Stapels DAC, Subari NZ, Pham THM, Brewer SM, Ong SYQ, Monack DM, Helaine S, Thurston TLM.
Cell Host Microbe. 2020 Jan 8;27(1):41-53.e6. doi: 10.1016/j.chom.2019.11.002. Epub 2019 Dec 17.

Bacterial Persisters and Infection: Past, Present, and Progressing.
Gollan B, Grabe G, Michaux C, Helaine S.
Annu Rev Microbiol. 2019 Sep 8;73:359-385. doi: 10.1146/annurev-micro-020518-115650

Definitions and guidelines for research on antibiotic persistence.
Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A.
Nat Rev Microbiol. 2019 Jul;17(7):441-448. doi: 10.1038/s41579-019-0196-3. Review. Erratum in: Nat Rev Microbiol. 

Clarifying the Link between Toxin-Antitoxin Modules and Bacterial Persistence.
Ronneau S, Helaine S.
J Mol Biol. 2019 Aug 23;431(18):3462-3471. doi: 10.1016/j.jmb.2019.03.019. Epub 2019 Mar 23. Review.

Salmonella persisters undermine host immune defenses during antibiotic treatment.
Stapels DAC, Hill PWS, Westermann AJ, Fisher RA, Thurston TL, Saliba AE, Blommestein I, Vogel J, Helaine S.
Science. 2018 Dec 7;362(6419):1156-1160. doi: 10.1126/science.aat7148.

Escherichia coli ItaT is a type II toxin that inhibits translation by acetylating isoleucyl-tRNAIle.
Wilcox B, Osterman I, Serebryakova M, Lukyanov D, Komarova E, Gollan B, Morozova N, Wolf YI, Makarova KS, Helaine S, Sergiev P, Dubiley S, Borukhov S, Severinov K.
Nucleic Acids Res. 2018 Sep 6;46(15):7873-7885. doi: 10.1093/nar/gky560.

Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection.
Rycroft JA, Gollan B, Grabe GJ, Hall A, Cheverton AM, Larrouy-Maumus G, Hare SA, Helaine S.
Nat Commun. 2018 May 18;9(1):1993. doi: 10.1038/s41467-018-04472-6

Persistent Bacterial infections and persister cells.
Fisher RA, Gollan B, Helaine S.
Nat Rev Microbiol. 2017 Aug:15(8):453-464. doi: 10.1038/nrmicro.2017.42. Epub 2017 May 22. Review

Toxin-antitoxin systems: reversible toxicity.
Hall AM, Gollan B, Helaine S.
Curr Opin Microbiol. 2017 Apr;36:102-110. doi: 10.1016/j.mib.2017.02.003. Epub 2017 Mar 6. Review.

Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella.
Saliba AE, Li L, Westermann AJ, Appenzeller S, Stapels DA, Schulte LN, Helaine S, Vogel J.
Nat Microbiol. 2016 Nov 14;2:16206. doi: 10.1038/nmicrobiol.2016.206.

A Salmonella Toxin promotes persister formation through acetylation of tRNA.
Cheverton AM, Gollan B, Przydacz M, Wong CT, Mylona A, Hare SA, Helaine S.
Mol Cell. 2016 Jul 7;63(1):86-96. doi: 10.1016/j.molcel.2016.05.002. Epub 2016 Jun 2.

Elucidating population-wide mycobacterial replication dynamics at the single-cell level.
Mouton JM, Helaine S, Holden DW, Sampson SL.
Microbiology. 2016 Jun;162(6):966-978. doi: 10.1099/mic.0.000288. Epub 2016 Mar 30.

Analysis of Macrophage-Induced Salmonella Persisters.
Fisher RA, Cheverton AM, Helaine S.
Methods Mol Biol. 2016;1333:177-87. doi: 10.1007/978-1-4939-2854-5_15.

Bacterial persisters: formation, eradication, and experimental systems.
Helaine S, Kugelberg E.
Trends Microbiol. 2014 Jul;22(7):417-24. doi: 10.1016/j.tim.2014.03.008. Epub 2014 Apr 23. Review.

Internalization of Salmonella by macrophages induces formation of nonreplicating persisters.
Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW.
Science. 2014 Jan 10;343(6167):204-8. doi: 10.1126/science.1244705.

Dynamics of intracellular bacterial replication at the single cell level.
Helaine S, Thompson JA, Watson KG, Liu M, Boyle C, Holden DW.
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3746-51. doi: 10.1073/pnas.1000041107. Epub 2010 Feb 2.